RESEARCH AND DEVELOPMENT

Human skin verrucas as well as gebital verrucas are known since ancient times. Already at the end of the last century, Variot and Judasohn proofed that it is possible to transfer them from person to person. In the meantime , members of the Papovaviridae, the human Papillomvirus (HPV), were identified as the etiologic agent.

The Papillom viruses are a group of small DNA-viruses, with extraordinary much different subtypes, that infect all superior vertebrates. We distinguish them between benign and malign subtypes. Albeit structural analogies, the individual subtypes show high differences regarding its tissue specificity and its transforming qualities.Papillom viruses infect the basal cells of the skin and the mucosa and activate them to divide themselves.
The viruses have a diameter of approx. 55 nm. They do not passess a capsula. In capsid consist of 72 capsomeres. Every capsomer is a pentamer of the major capsidproteins (L 1-protein). Furthermore, the capsid contains a minor protein (L 2-protein), that has a proportion of 3 - 5 % on the complete protein.
The genome of Papillom viruses consists in approx. 8 kb double-strand, circular DNA. The DNA is associated in virions and histons and builds them a structure simular to chromatin. The genetic organisation of all Papillom viruses is similar.


.

Some years ago there were achieved particles similar with a virus (VLP) through expressions of the capsid genes- It is not possible to difference them from infectious virus with an electronic microscope.

go on to researching details from Papillom virus